{"id":1209,"date":"2021-02-24T23:21:49","date_gmt":"2021-02-24T22:21:49","guid":{"rendered":"https:\/\/hanfserver.info\/?p=1209"},"modified":"2021-02-24T23:21:51","modified_gmt":"2021-02-24T22:21:51","slug":"cannabinoids-could-limit-brain-injury-damage-researchers-say","status":"publish","type":"post","link":"https:\/\/hanfserver.info\/?p=1209","title":{"rendered":"Cannabinoids Could Limit Brain Injury Damage, Researchers Say"},"content":{"rendered":"\n
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Most patients would benefit from some kind of intervention that could help balance the body\u2019s natural inflammatory response. (Shutterstock)<\/figcaption><\/figure><\/div>\n\n\n\n

This article was first published on\u00a0Analytical Cannabis. It appears here with permission.<\/em><\/p>\n\n\n\n

The initial effects of a traumatic brain injury are severe. Fractures, soft tissue lacerations, and intracranial hemorrhage are all common injuries in the aftermath of such an injury. But in the days following the moment of injury, excessive inflammation inside the skull can continue to cause\u00a0further secondary brain damage.<\/p>\n\n\n\n

While some\u00a0traumatic brain injury (TBI)\u00a0patients are able to make excellent recoveries, most would benefit from some kind of intervention that could help balance the body\u2019s natural inflammatory response.<\/p>\n\n\n\n

Now, a research group at the Medical College of Georgia at Augusta University has been\u00a0awarded a $1.8 million grant\u00a0from the National Institute of Neurological Disorders and Stroke to investigate how the body\u2019s endocannabinoid system might potentially limit the secondary damages caused by this inflammation.<\/p>\n\n\n\n

The endocannabinoid system and brain trauma<\/h2>\n\n\n\n

The research group, led by principal investigator and translational neuroscientist Dr Kumar Vaibhav, has previously looked into\u00a0the role of\u00a0the endocannabinoid system\u00a0following TBI.<\/p>\n\n\n\n

Immediately after a TBI, the injured brain cells\u2019 plasma membrane begins to rupture, releasing the lipids and fats that make up the membrane throughout the body. Two major endocannabinoids, 2-arachidonoylglycerol (2-AG) and N-arachidonoylethanolamine (AEA), are also released; both are lipid molecules\u00a0enzymatically formed\u00a0from compounds in the brain cell membrane.<\/p>\n\n\n\n

These endocannabinoids are intended to go and bind with the endocannabinoid receptors in the body to naturally regulate the immune response. Specifically, 2-AG appears to target the CB2 endocannabinoid receptor, which is largely expressed in immune cells and is thought to\u00a0modulate immune function\u00a0and the\u00a0anti-inflammatory response.<\/p>\n\n\n\n

The catch is that the injured membrane also releases an enzyme known as MAGL, which is activated by the other free-floating lipids released by the membrane. MAGL, or monoacylglycerol lipase, metabolizes endocannabinoids such as 2-AG. Activation of MAGL is known to worsen the outcomes for TBI patients, but the exact mechanism behind this is not yet fully understood.<\/p>\n\n\n\n

Inhibition of MAGL using cannabinoids<\/h2>\n\n\n\n

Vaibhav and his colleagues theorize that high levels of activated MAGL could be degrading 2-AG before it is able to reach the endocannabinoid receptors, cutting off a part of the body\u2019s natural anti-inflammatory response.<\/p>\n\n\n\n

In\u00a0previous research, the team found reduced levels of 2-AG in the cerebrospinal fluid of TBI patients, but it was unclear why this arose. In a laboratory model, they also found MAGL levels to be high when 2-AG levels are low, implying that there is a link between the two compounds.<\/p>\n\n\n\n

The research at the focus of the new $1.8 million grant will look at what effect the early inhibition of MAGL in the immune cells \u2013 achieved via cannabidiol (CBD) and synthetic versions of the endocannabinoids 2-AG and AEA \u2013 might have on the sustained secondary inflammation response that occurs after a TBI.<\/p>\n\n\n\n

\u201cWe are looking into how to suppress MAGL so that you still have enough 2-AG to expedite the recovery process after TBI,\u201d Vaibhav tells Analytical Cannabis<\/em>.<\/p>\n\n\n\n

\u201cWe\u2019re proposing research on why to suppress MAGL, and what it does. Whether it\u2019s going to suppress that inflammation or not. And because MAGL is endogenous and is necessary for many other processes, we don\u2019t want to suppress this and it cause some unwanted side effects.\u201d<\/p>\n\n\n\n

For example, the team also wants to know whether high levels of the MAGL enzyme and a subsequent reduced activation of the CB2 receptor might affect other parts of the brain, such as the white matter. This brain tissue is home to the nerve fibers that allow connections between the different parts of the brain and the spinal cord.<\/p>\n\n\n\n

Why, how, and when intervene?<\/h2>\n\n\n\n

Working out how this secondary inflammation develops, and which drugs can attenuate its negative effects, is only one part of the problem. In order to be properly effective, scientists will also have to pinpoint exactly when to use these kinds of interventions.<\/p>\n\n\n\n

Apply a drug too quickly or suppress too much of the pro-inflammatory process, and there is a risk that the initial beneficial inflammatory response that\u00a0protects the brain\u00a0from invading pathogens and stimulates cell repair might be interrupted.<\/p>\n\n\n\n

\u201cThe first immune cells to arrive at a site of injury are scavenger cells,\u201d Vaibhav explains. \u201cThose cells come to the injured site and their first goal is to clear the debris. They scavenge up the dead cells and \u2018clear the path\u2019 for other cells to come and begin repair.\u201d<\/p>\n\n\n\n

\u201cIf you suppress the inflammatory response there and start anti-inflammatory treatment too early, it is going to hamper the entire recovery process. The scavenger cells need that time to clear around the injured part so that repair can begin.\u201d<\/p>\n\n\n\n

Investigating optimal timing and optimal dose of MAGL suppression is a key component of the work for Dr Vaibhav and his colleagues, and one that they have already made some headway in.<\/p>\n\n\n\n

The team previously established that the body\u2019s macrophages \u2013 a type of immune cell that stimulates tissue repair at injury sites \u2013 shift from their normal role of suppressing inflammation to\u00a0chronically promoting it\u00a0around a month after a TBI. When these immune cells stay activated for too long, they begin a harmful inflammation cycle where they start to digest healthy brain tissue, promote further inflammation, and damage wider parts of the brain.<\/p>\n\n\n\n

For enzymes like MAGL, Vaibhav explains, once they are activated, they instinctively want to stay active for as long as possible. If the team\u2019s hypothesis is correct, that high MAGL levels could be somehow suppressing an anti-inflammatory response, which is why they believe it is crucial that more time-focused studies be carried out on this enzyme.<\/p>\n\n\n\n

Quelle<\/a><\/p><\/blockquote><\/figure>\n","protected":false},"excerpt":{"rendered":"

This article was first published on\u00a0Analytical Cannabis. It appears here with permission. The initial effects of a traumatic brain injury are severe. Fractures, soft tissue lacerations, and intracranial hemorrhage are all common injuries in the aftermath of such an injury. But in the days following the moment of injury, excessive<\/p>\n

WeiterlesenCannabinoids Could Limit Brain Injury Damage, Researchers Say<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-1209","post","type-post","status-publish","format-standard","hentry","category-medizinisches"],"_links":{"self":[{"href":"https:\/\/hanfserver.info\/index.php?rest_route=\/wp\/v2\/posts\/1209","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hanfserver.info\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hanfserver.info\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hanfserver.info\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hanfserver.info\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1209"}],"version-history":[{"count":1,"href":"https:\/\/hanfserver.info\/index.php?rest_route=\/wp\/v2\/posts\/1209\/revisions"}],"predecessor-version":[{"id":1211,"href":"https:\/\/hanfserver.info\/index.php?rest_route=\/wp\/v2\/posts\/1209\/revisions\/1211"}],"wp:attachment":[{"href":"https:\/\/hanfserver.info\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1209"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hanfserver.info\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1209"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hanfserver.info\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1209"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}